As shown in Figures 2A,B, both serum adropin and irisin levels of patients in the CAD group were significantly lower than those of the non-CAD group (adropin: 2182.7 ± 132.6 vs. 2945.7 ± 194.5 pg/l, P < 0.001; irisin: 175.0 ± 26.1 vs. 222.8 ± 16.4 μg/l, P < 0.001). The gene discussed is FNDC5; the disease is coronary artery disorder.