We observed no evidence that there were shared causal variants between LDL-C and RCC risk in men at PCSK9 locus (rs11206510, CLPP = 0.004) and in women at CETP locus (rs247616, CLPP = 0.004) for a-priori defined CLPP threshold of 0.10. The gene discussed is PCSK9; the disease is renal cell carcinoma.