HMGCR and renal cell carcinoma: We did not observe a significant association between genetically proxied HMGCR inhibition, which was equivalent to one SD reduction in LDL-C, and RCC risk [Odds ratio [OR] = 1.42, 95% CI, 0.29–6.99, P = 0.668]; and this association remained non-significant when classified by sex [men: OR = 1.25 [95% CI, 0.56–2.79], P = 0.583; women: OR = 0.97 [95% CI: 0.36–2.66], P = 0.956].