Dysregulated EMT, EndMT and myofibroblastoid differentiation are seen in fibrotic diseases, vascular malformations, epithelial dedifferentiation and tumor growth; in advanced stages of cancers, TGF-β-induced EMT promotes tumor invasion, metastasis, and chemo-resistance (Tsubakihara and Moustakas, 2018; Katsuno and Derynck, 2021). The gene discussed is TGFB1; the disease is neoplasm.