In mouse models blocking of αvβ8 by monoclonal antibodies suppresses growth of squamous cell carcinoma, mammary cancer, colon cancer and prostate cancer, emphasizing the role αvβ8/TGF-β mediated immune tolerance of tumors (Dodagatta-Marri et al., 2020). The gene discussed is TGFB1; the disease is malignant colon neoplasm.