Furthermore, tumor derived TGF-β together with other cytokines shifts the balance of tumor associated macrophages (TAM) and neutrophils (TAN) from TAM1 toward pro-tumorigenic TAM2 (Gong et al., 2012) and from TAN1 toward pro-tumorigenic TAN2 (Fridlender et al., 2009). This evidence concerns the gene TGFB1 and neoplasm.