For example, in the Hippo pathway, WWP1 executes its tumorigenic function by targeting LAST1 for degradation (Yeung et al., 2013), while two other components of this pathway, YAP and TAZ, antagonize WWP1-mediated degradation of KLF5 and consequently promote growth and metastasis of some breast and prostate cancers (Zhao et al., 2012; Zhi et al., 2012). The gene discussed is KLF5; the disease is prostate cancer.