KITLG and neoplasm: Production of CXCL12 by tumor cells attracts mast cells to the TME and promotes secretion of pro-angiogenic factors such as VEGF-A, heparin, histamine, and SCF (Jorpes, 1959; Theoharides et al., 1982; Kim et al., 1993; Kryczek et al., 2005; Beer et al., 2008; Carmeliet and Jain, 2011; Kolset and Pejler, 2011; Vizio et al., 2013; Derakhshani et al., 2019).