Mast cells also produce CXCL8/IL-8 which can induce epithelial-to-mesenchymal transition (EMT) in which tumor cells acquire metastatic features and resistance to chemotherapy (Scheel and Weinberg, 2012; Visciano et al., 2015; Zheng et al., 2015). The gene discussed is CXCL8; the disease is neoplasm.