Of the resulting models, those with solely Brca2-deficiency (CBTr/Δ11: Pdx1-Cre; Brca2Tr/Δ11) had a longer survival than those with combined Brca2-deficiency and Trp53 loss (PCBTr/Δ11: Trp53R270H, Pdx1-Cre; Brca2Tr/Δ11 and PCBTr/WT: Trp53R270H, Pdx1-Cre; Brca2Tr/WT) which the researchers contribute to development of pancreatic insufficiency in a fraction of mice. The gene discussed is PDX1; the disease is exocrine pancreatic insufficiency.