The number of CD8+ T cells, CD4+ T cells, macrophages, and tumor-associated fibroblasts in TME is associated with the clinical outcome of many malignant tumors, such as gastric cancer, urothelial cancer, lung cancer, and breast cancer (Fridman et al., 2017; Mantovani et al., 2017; Nishino et al., 2017; Mariathasan et al., 2018). Here, CD4 is linked to neoplasm.