Analysis of the proportion of immune cells in tumor tissue of two groups divided by the TMEscore showed that the proportions of M1 macrophages, CD8+ T cells, and activated CD4+ memory T cells were increased in the high TMEscore group (Figures 2C,D), as well as the IFN-gamma related genes (Supplementary Figure 2B). This evidence concerns the gene IFNG and neoplasm.