EWSAT1 and osteosarcoma: Tao et al. reported that Ewing sarcoma associated transcript 1 (EWSAT1; also known as linc-00277) regulated osteosarcoma-induced angiogenesis via a “double stacking effect,” through which exosomes-carrying EWSAT1-induced increased sensitivity of vascular endothelial cells and EWSAT1-induced increased secretion of angiogenic factors in osteosarcoma cells, and by transporting EWSAT1 from osteosarcoma cells to vascular endothelial cells, these exosomes play a crucial role in this process (Tao et al., 2020).