More recently, Wang et al. demonstrated that ADSC-secreted exosomes can activate the expression of Homosapien collagen beta galactosyl transferase 2 (COLGALT2) in osteosarcoma cells, thereby increasing vimentin and MMP expression to promote osteosarcoma growth and metastasis (Figure 4; Wang Y. et al., 2020). This evidence concerns the gene COLGALT2 and osteosarcoma.