Ge et al. reported that BMSC derived exosomal LCP1 promotes osteosarcoma progression through the JAK2/STAT3 pathway, and miR-135a-5p could interact upstream of LCP1 to cancel tumorigenesis of osteosarcoma influenced by LCP1 (Ge et al., 2020). The gene discussed is STAT3; the disease is osteosarcoma.