Gong et al. observed that invasion and migration of non-malignant osteoblast cells (hFOB 1.19) were increased by exposure to exosomes derived from metastatic osteosarcoma by delivering exogenous miR-675 and downregulating target genes within recipient cells such as CALN1 (Gong et al., 2018). The gene discussed is CALN1; the disease is osteosarcoma.