Zong et al. demonstrated for the first time that osteosarcoma cells carrying the RAB22A-NeoF1 fusion gene acts as a metastasizing driver that may secrete exosomes containing RAB22A-NeoF1 into the osteosarcoma microenvironment, thereby affecting the characteristics of RAB22A-NeoF1-negative osteosarcoma cells. The gene discussed is RAB22A; the disease is osteosarcoma.