Further studies have shown that PYK2 was enriched in osteosarcoma derived exosomes by binding to the RAB22A-NeoF1 fusion protein, thereby inducing RhoA activation in RAB22A-NeoF1-negative receptor osteosarcoma cells to promote their migration, invasion, and lung metastasis (Zhong et al., 2021). Here, RHOA is linked to osteosarcoma.