Han et al. reported that osteosarcoma cell derived exosomal miR-1307 targets AGAP1, which is an Arf GTPase-activating proteins (Arf GAPs) that depends on phosphoinositide to promote the proliferation, invasion and migration of osteosarcoma cells, while upregulation of AGAP1 could significantly inhibit the function of miR-1307 in osteosarcoma (Han et al., 2021). This evidence concerns the gene CDKN2A and osteosarcoma.