Torreggiani et al. reported that multidrug-resistant osteosarcoma cells are able to transfer osteosarcoma derived exosomes carrying MDR-1 mRNA and its product P-glycoprotein so as to spread their resistance to doxorubicin treatment on sensitive osteosarcoma cells (Torreggiani et al., 2016). This evidence concerns the gene ABCB1 and osteosarcoma.