Zhang et al. demonstrated that lncRNA cancer susceptibility 15 (CASC15) is upregulated in osteosarcoma plasma exosomes, and by targeting the miR-338-3p/RAB14 axis, downregulation of CASC15 inhibited the progression of osteosarcoma including proliferation, migration, and invasion (Zhang et al., 2020b). Here, CASC15 is linked to osteosarcoma.