Baglio et al. reported that the osteosarcoma-secreted exosomes carry functional TGFβ molecules that increase IL-6 expression to promote osteosarcoma growth and metastasis formation, and the combination of IL-6 blocking agents with TGFβ inhibitors could stop osteosarcoma progression while reducing drug resistance (Baglio et al., 2017). This evidence concerns the gene IL6 and osteosarcoma.