Furthermore, BMP4 was capable of inducing tumor dormancy via activating SMAD1/5 signaling (Gao et al., 2012) and BMP7 can inhibit tumor cell growth and drive CSCs into dormancy by mediating the expression of N-myc downstream-regulated gene 1 and activating p38 MAPK and p21 signaling pathways (Kobayashi et al., 2011; Widner et al., 2018). The gene discussed is SMAD1; the disease is neoplasm.