CSF3 and neoplasm: According to MDA-MB-231BCCs phenotype analysis, there is an obvious up-regulation of various cytokines/chemokines such as CXCL1, CXCL2, GCSF IL-1α, IL-1β, IL-8, and PAI-1 (SERPINE1), all of which are integral to the expression of the senescence-associated secretory phenotype, an important mediator in regulating tumor dormancy and relapse, which could induce tumor dormancy via activating cytokine and chemokine signaling, inhibiting cell proliferation and vascular development and initiating inflammatory/immune response (Özcan et al., 2015; Bartosh, 2017).