RAF1 and neoplasm: Current studies have reported that acidic tumor microenvironment was capable of promoting tumor dormancy through various mechanisms, such as increasing the percentage of cells in the G0 phase, regulating growth factor signaling and Raf/ERK pathway, increasing phosphorylation metabolism, leading to high resistance to apoptosis and autophagy, as well as hiding from immune surveillance (Peppicelli et al., 2017).