• PB and TNFR2+Treg TILs significantly elevated in patients with cervical intraepithelial neoplasia and cancer• Circulating s-TNFR1 and s-TNFR2 elevated in cervical cancer patients• Percentage of peripheral TNFR2+Tregs inversely correlates with the clinical stage of cervical cancer. The gene discussed is TNFRSF1B; the disease is cervical cancer.