The first remarkable observation concerning TNFR2 in the context of cancer was the decrease in tumor growth and metastasis described in TNFR2 knockout mice, despite the TNFR2 costimulatory function on Teffs (Sasi et al., 2012; Chopra et al., 2013; Ham et al., 2015). Here, TNFRSF1B is linked to neoplasm.