• In TNFR2–/– mice with colon (MC-38) or lung (H-59) carcinoma, metastasis and Tregs accumulation are reduced• In WT mice, treatment with TNFR2 antisense oligodeoxynucleotides inhibits hepatic metastasis• In mice with TNFα- or TNFR2 immune cell-restricted deficiency, melanoma (B16F10-Luc) metastasis to the lung and numbers of Treg infiltration in lungs are decreased. Here, TNF is linked to carcinoma.