In turn, it appears that TNFR2 overexpression by cancer cells in a model of colon carcinoma (CT26) is associated with a greater presence of TNFR2+ Tregs in draining lymph nodes and four time more sTNFR2 in the peripheral blood (Chen et al., 2018). The gene discussed is TNFRSF1B; the disease is colon carcinoma.