• Higher proportion of CD4+CD25hiTNFR2+ Tregs in tumor ascites• Up-regulation of CD39, CD73, GARP, and TGF-β in this subpopulation• TNFR2+ Tregs dampen local IFN-γ and IL-2 production by Teff (more than blood Tregs). The gene discussed is CD4; the disease is neoplasm.