TNFRSF1B and neoplasm: Indeed, TNFR2-dependant NF-κB activation in epithelial cells induces carcinogenesis and the absence of this mechanism may have taken part as well in the observed impairment of tumor growth in TNFR2–/– mice (Onizawa et al., 2009; Suzuki et al., 2014; Nagaishi et al., 2016).