Our observations are consistent with the fact that TNFR2–/– mice do not develop autoimmunity, suggesting that the restriction of TNFR2 on a Treg subset in the steady-state does not impair the capacity of other subpopulations to maintain an immune balance (Vanamee and Faustman, 2017). Here, TNFRSF1B is linked to Autoimmunity.