In renal clear cell carcinoma, CDKN2B-AS1 exerts its carcinogenic activity by recruiting CREB-binding protein and three epigenetic modification complexes containing SET and MYND domains to the promoter region of the Ndc80 mitochondrial complex (NUF2) (Xie et al., 2021). Here, NUF2 is linked to clear cell renal carcinoma.