However, in contrast to clear roles played in AD and DM2 pathologies (Li et al., 2018) and in male reproduction (Meneses et al., 2019), the role of IDE remains hypothetical in muscle development, only suggested by studies in mouse and rat myoblast cell lines (Kayalar and Wong, 1989; Epting et al., 2008). The gene discussed is IDE; the disease is Alzheimer disease.