ICAM1 and melanoma: Among them, the β2-integrin Leucocyte Functional Antigen (LFA)-1, recognizing the Intercellular Adhesion Molecule (ICAM)-1, is found to be expressed on melanoma cells (40, 41), where it plays a central role in mediating the firm adhesion between NK and target cells as well as the polarized delivery of cytotoxic granules (42).