CXCL2 and neoplasm: Some possible mechanisms underlying adipocytes-induced peritoneal metastasis include induction of angiogenesis via the CXCL2-VEGFA axis (40), activation of the PI3K/AKT/mTOR pathway by producing MCP-1 (41),upregulation of CD36 in tumor cells (42), and fatty acid metabolic reprogramming (43).