According to KEGG functional analysis, the FRGs were mainly enriched in renal cell carcinoma, lysosomes, FCγR-mediated phagocytosis, the phosphatidylinositol signaling system, proteasomes, maturity onset diabetes of the young, olfactory transduction, phenylalanine metabolism, proximal tubule bicarbonate reclamation, and the terpenoid backbone biosynthesis pathway. Here, FCGR2A is linked to hereditary clear cell renal cell carcinoma.