Several studies have demonstrated that some diffusion coefficients derived from intravoxel incoherent motion (IVIM), diffusion kurtosis imaging (DKI) or stretched-exponential models such as slow apparent diffusion coefficient (ADCslow), axial kurtosis and heterogeneity index α could correlate with Ki-67 expression in gliomas (4, 19, 20), whilst the DKI-derived mean kurtosis, diffusion tensor imaging-derived mean diffusivity, the apparent ADC and ADC derived from ultra-high b-value model showed different correlation tendency with AQP in gliomas (5, 21). The gene discussed is MKI67; the disease is glioma.