In general, CRC can be roughly classified according to the following criteria (1): APC-status (mutated or wild-type) (2); microsatellite status (stable or unstable, MSS or MSI) (3); KRAS status (mutated or wild-type) (4); BRAF status (mutated or wild-type) (5); methylation status (CpG Islands methylation phenotype high or low, CIMP-H or CIMP-L) (6, 8, 9). This evidence concerns the gene BRAF and colorectal carcinoma.