Other involved genes were ARID1A, CDK12, CTNNB1, KIT, MSH6, ERBB3, RAD51D. Truncating mutations of ARID1A, a chromatin remodeler, have been related to the development of endometrioid carcinoma of the ovary (47) and of early CRC (48). The gene discussed is CDK12; the disease is colorectal carcinoma.