INS and type 2 diabetes mellitus: In this regard, Taylor et al. found that negative attitudes toward insulin use were related to the deterioration of T2DM with insulin, family and friends’ concerns, injection pain, hypoglycemic risk, increased dependence on physicians, need for increased efforts, the difficulty of dosing accuracy, weight gain, inconveniences in daily life, health deterioration, and inconveniences in engagement in preferred activities [19].