We explored the effect and molecular mechanism of LPR6 on cardiomyocyte ferroptosis by establishing a model of MI in vivo and in vitro, constructed the regulatory network of circRNA-miRNA-LRP6 by bioinformatics analysis, and tested the molecular mechanisms of circRNA1615 regulating ferroptosis in the RIP experiment and using the double luciferase reporter gene assay. The gene discussed is LRP6; the disease is myocardial infarction.