Several studies have showed that ox-LDL is an independent determinant of ED in both CKD and HD populations [21, 22], whereas the hyperglycemic environment along with ox-LDL triggers overproduction of asymmetric dimethylarginine (ADMA) which in turn promotes endothelial nitric oxide synthase uncoupling to form ROS [20]. This evidence concerns the gene NOS3 and Huntington disease.