BCL2 and breast adenocarcinoma: A few compounds isolated from E. scaber also showed significant cytotoxicity and antiproliferation activities on MCF-7 cells: Lupeol (a triterpeniod) induced MCF-7 cell apoptosis via downregulated Bcl-2 and Bcl-xL protein expressions [37], scabertopinolide G exhibited strongest cytotoxity towards MCF-7 among all the other 7 germacranolides [38], and deoxyelephantopin (a germacranolide sesquiterpene lactone) induced apoptosis in MCF-7 and mammary adenocarcinoma TS/A cells [39].