Both HASP5 knockdown and EEF2 knockdown can significantly restore PRMT7 overexpression-induced NSCLC invasion, indicating that PRMT7 promoted metastasis in NSCLC likely through interacting with HSPA5 and EEF2, which provides information on the mechanism of lung cancer metastasis and a candidate target gene in lung cancer. The gene discussed is HSPA5; the disease is lung carcinoma.