SHANK2 and cancer: In addition to direct inhibition and automethylation, a recent study discovered that PRMT7 promoted the metastasis of human breast cancer by methylating the arginine of SHANK2 (SH3 and multiple ankyrin repeat domains 2), consequently activating endosomal FAK (focal adhesion kinase) signaling [55], which led to cancer cell growth to a malignant phenotype [56].