However, although this study shows that serum NTproBNP levels have a higher effect on PDA of premature infants High predictive value, but there is still a certain proportion of missed diagnosis rate and misdiagnosis rate, suggesting that the sample size needs to be increased for further research to determine the best diagnostic value of NT-proBNP for early prediction of PDA. Here, NPPB is linked to Patent ductus arteriosus.