Biallelic mutations in the AEBP1 gene, encoding AEBP1, cause an EDS phenotype hallmarked by skin hyperextensibility with atrophic scarring, generalized joint hypermobility, foot deformities and early-onset osteopenia, provisionally referred to as classical-like EDS type 2 (clEDS2) (Blackburn et al., 2018; Syx et al., 2019). This evidence concerns the gene AEBP1 and Osteopenia.