TNXB and Ehlers-Danlos syndrome due to tenascin-X deficiency: Additional studies in Tnxb–/– mice revealed the presence of reduced femoral bone mass with enhanced osteoclast differentiation and bone-resorbing ability (Kajitani et al., 2019), very mild genito-urinary complications (rectal prolapse in <1%) in female mice compared to uterine and vaginal prolapse seen in clEDS patients (Egging et al., 2008), attenuated stromal neovascularization following cauterization (Sumioka et al., 2018) and gastric dysfunction associated with abnormal gastric sensory function (Aktar et al., 2019).