For example, CDK16, a kinase that regulates the vesicle-mediated transport processes and exocytosis was found exclusively in control samples, whereas kinases involved in the microtubule-associated protein tau (Tau) phosphorylation, such as serine/threonine-protein kinase MARK2 and tau-tubulin kinase 1 were predominant in AD samples (SupplementaryTable S2). This evidence concerns the gene MARK2 and Alzheimer disease.