In contrast, up-regulated proteins in AD brains, such as baculoviral IAP repeat-containing protein 2, baculoviral IAP repeat-containing protein 6 and ADP-ribosylation factor-like protein 2 are related to the modulation of apoptosis and inflammatory signaling (Figures 3C, D and Supplementary Table S3). Here, BIRC6 is linked to Alzheimer disease.