Proteins with increased levels in AD condition are mainly linked to TCR-activation and NF-κB-mediated transcription, such as F-box/WD repeat-containing protein 1A and receptor-type tyrosine-protein phosphatase C. However, another set of proteins, such as protein arginine N-methyltransferase 2, involved in NF-κB inhibition were also up-regulated in AD. The gene discussed is BTRC; the disease is Alzheimer disease.