On the other hand, phosphosites, which exhibited an increased level of phosphorylation in AD condition were mainly linked to cytoskeletal organization and ubiquitination (e.g., E3 ubiquitin-protein ligase UBR4), apoptosis mediation and stress fiber dissolution (e.g., STE20-like kinase), lysosome movement and stabilization of endoplasmic reticulum (e.g., BLOC-1-related complex subunit 5 and reticulon-4). This evidence concerns the gene RTN4 and Alzheimer disease.