Additionally, phosphopeptides and phosphosites with higher abundances in AD compared to control patients were related to glutamatergic neurotransmission (e.g., calcium/calmodulin-dependent protein kinase type II subunit alpha, glutamate receptor-interacting protein 1, and glutamate receptor ionotropic, NMDA 2B). The gene discussed is GRIN2B; the disease is Alzheimer disease.