CD4 and infection: Immunization with LdCen-/- parasites showed that LdCen-/–infected DCs produce IL-1β, IL-6, and TGF-β to promote the development of Th17 lineage, and upon virulent challenge with wild-type L. donovani (LdWT) infection both CD4 and CD8 T cells produced IL-17, resulting in protection (184).