In consequence, the renewal of a pool of T cells from a senescence aspect to a functional profile can restrain or decrease the CMV infection, which can also reduce the antigenic stimulus and the number of “older” CMV-specific T cells, leading to the control of CMV reactivation (47, 51), since around 25% of the CD8+ T cells can show specificity for a unique CMV-immunodominant epitope in CMV-seropositive older adults (29). This evidence concerns the gene CD8A and cytomegalovirus infection.