In addition, as the vital source of immune regulation, our analysis in regard to checkpoints indicates TNFSF13 closely synergistic with PDCD1LG2, HAVCR2, PDCD1, CD80, CTLA4, CD274, IDO1, and CD276 in pan-gliomas, LGGs, GBMs, and pan-cancer. Here, PDCD1LG2 is linked to central nervous system cancer.