TNFSF13 was proved to interact with two receptors: B cell maturation antigen (BCMA), which germanely combined with TNFSF13 to induce tumor cell invasion and immunosuppression (27, 28); the other one is transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), which have both positive and negative regulation to B cell activity (29). This evidence concerns the gene TNFSF13 and neoplasm.