Meanwhile, some genetic alterations correlated with heterogeneous tumor histology were detected, including 1p/19q codeletion and IDH mutation (45), TNFSF13 expression was found amplified in 1p/19q non-codeletion glioma samples (Figure 1B), and compared to IDH mutation cases, the expression of TNFSF13 enhanced in IDH wild-type gliomas of all WHO grades (Figure 1C). Here, TNFSF13 is linked to central nervous system cancer.