Based on TCGA and CGGA datasets, we observed a high and positive correlation between TNFSF13 and PDCD1LG2, HAVCR2, CTLA4, and other checkpoint molecules in pan-gliomas, LGG and GBM analysis, and TNFSF13 expression is tightly correlated with HAVCR2 in glioblastomas (Supplementary Figures S11A, B). Here, PDCD1LG2 is linked to central nervous system cancer.