Then we evaluated TNFSF13 expression based on World Health Organization (WHO) classification and histology, which showed the expression of TNFSF13 was enhanced in GBM (WHO grade IV) compared with LGG (WHO grade II and III) cases (Figure 1A), and TNFSF13 level was upregulated in higher histopathologic malignancies (Supplementary Figure S1C). Here, TNFSF13 is linked to glioblastoma.