AMPK participates in the cardiovascular protection effect of Rb1 against reperfusion injury/myocardial ischemia, coronary atherosclerotic, heart failure, cardiac hypertrophy, and fibrosis by mediating apoptosis (Kong et al., 2010), autophagy (Qiao et al., 2017; Dai et al., 2019), mitochondrial fission (Li et al., 2016), fatty acid β-oxidation (Kong et al., 2018), and aging (Zheng et al., 2020). Here, RB1 is linked to heart failure.