IL6 and central nervous system cancer: In recent years, many studies have shown that some inflammatory cells (such as neutrophils and macrophages), inflammatory factors (IL-8, IL-1beta, IL-6, CD8+, and CXCL16) in the inflammatory microenvironment of glioma, and related signal pathways (NF-κB and STAT-3) are closely related to the progression and prognosis of glioma (Müller et al., 2017; Albrengues et al., 2018; Greten and Grivennikov, 2019; Zha et al., 2020).