Zhang W et al. reported that the upregulated IL-6 in liver cancer can downregulate the O-type protein tyrosine phosphatase receptor (PTPRO) by activating JAK2/STAT3 signal transduction, resulting in high PD-L1 expression, inducing immunosuppression and promoting tumor growth (Zhang et al., 2020). The gene discussed is JAK2; the disease is neoplasm.