CALCRL and central nervous system cancer: In addition, Benes L et al. have demonstrated that CRLR is widely distributed in human gliomas of different grades; at the same time, their team revealed that the possible mechanism of CRLR in gliomas is related to its influence on the formation of blood vessels, which assists the growth of gliomas (Ouafik et al., 2002; Benes et al., 2004).