The activation of NLRP3 inflammasome is also a vital mediator of NASH progression, which is closely related to the pathological progress of NASH, while blocking this signaling pathway has been reported as an efficient therapeutic approach to alleviate steatosis, inflammation, and even fibrosis in NASH model induced by MCD diet feeding (Mridha et al., 2017; Mahzari et al., 2019). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatohepatitis.