MYC and obesity due to melanocortin 4 receptor deficiency: Besides, Shjie et al. (Liu et al., 2017) found that the expression of c-MYC was increased in high-fat-fed mice whose RPL11 binding was disrupted, thereby up-regulating the biogenesis of ribosomes and promoting nutrient absorption through the RPL11-MDM2-p53 pathway, resulting in obesity-related metabolic changes.