ACE2 and pulmonary edema: The W/D ratio in the IR group (W/D = 4.48 ± 0.22) and IR + ACE2-inhibited group (W/D = 4.63 ± 0.55) was significantly higher than in the SHAM group (W/D = 2.99 ± 0.80; W/D SHAM vs. IR group, SHAM vs. IR + ACE2-inhibited group, p < 0.05, respectively), whereas DIZE could significantly alleviate pulmonary edema after IR injury (IR + DIZE group W/D = 3.86 ± 0.33, p < 0.05, vs. IR group).