As shown in Figure 7, in the IR group and in the IR + ACE2-inhibited group, there was increased expression of p38MAPK and p65NF-κB during lung IR injury (level of p38MAPK SHAM vs. IR group, p < 0.01, SHAM vs. IR + ACE2-inhibited group, p = 0.064; level of p65NF-κB SHAM vs. IR group, p < 0.01, SHAM vs. IR + ACE2-inhibited group, p < 0.01). This evidence concerns the gene ACE2 and medical procedure.