MAPT and Alzheimer disease: Inorganic selenium and organic selenium compounds (sodium selenite, sodium selenate, selenomethylselenocysteine, ebselen, etc.)have been reported to improve antioxidant ability, reduce the pathology of Aβ and tau, ameliorate synaptic deficits, and improve cognitive defects in AD mice (Van Rhijn et al., 1990; Van Eersel et al., 2010; Xie et al., 2017, 2018).