PRDX6 and Alzheimer disease: Furthermore, Redox proteomics studies found that many antioxidant enzymes that are allocated in the mitochondria, including glutathione-S-transferase Mu, peroxiredoxin 6, GSH and ATP synthase are oxidized in AD, which might compromise their functions by increasing oxidative stress conditions that prevail in AD affected brain regions (Swomley and Allan Butterfield, 2015).