CLOCK and Alzheimer disease: MiR-125a, miR-125b, miR-146a have high diagnostic potential to predict AD progression, where they modulate Tau hyperphosphorylation (Nagaraj et al., 2019), inflammatory responses and autophagy in microglia and astrocytes, while regulating PER genes in the circadian clock (Lee et al., 2016; Liang et al., 2021).