ACE and Alzheimer disease: Kunkle et al. (2019), confirmed 20 previous LOAD risk loci and identified five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10 and ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of AD or dementia.