Mutations in the gene encoding SH3 and multiple ankyrin repeat domains 3 (SHANK3), a postsynaptic scaffolding protein, have been discovered in ASD patients, making it a prominent autism gene candidate (Gauthier et al., 2009; Phelan and McDermid, 2012; Boccuto et al., 2013). Here, SHANK3 is linked to autism.