Nevertheless, the changes found in the ALX-treated group seem to make more sense in the context of diabetes, since a hyperglycemic environment leads to an increase in proinflammatory cytokines, causing deleterious effects in the body, followed by an increase in CD8+ T cells [65], which might be correlated with a profuse expression of MHC class I observed in autoimmune diabetes [66]. The gene discussed is CD8A; the disease is diabetes mellitus.