SLC5A2 and hydrops fetalis: Although initial data from the outcome trials of empagliflozin and sotagliflozin (mixed SGLT1/2 inhibitor) suggest that they also reduce the risk of CV death and HF hospitalization in patients with HFpEF, the effects of SGLT2 inhibitors on patient-reported symptoms, physical limitations and objectively measured exercise function in this patient group remain uncertain14,15.