CSF3 and Sepsis: Megakaryocytes and their progenitors are suppressed by Myd88/TRIF.22 Granulopoiesis, or the production of neutrophils, is favoured in the septic bone marrow by TLR 4/TRIF signalling to produce granulocyte colony-stimulating factor (G-CSF), leading to depletion of megakaryocytes and their precursors.31 In severe sepsis this leads to unchecked proliferation of monocytes from granulocyte/macrophage progenitor cells.