These EVs allow communication by packaging cellular contents (nucleic acids, proteins, lipid mediators) and allowing them to be taken up by distant cells.115 Platelet-derived EVs (EVs) are among the highest concentration in peripheral circulation.116 EVs contain many of the immune mediators, including cytokines, chemokines, complement factors and surface receptors such CD40L.117–120 They may act as important “warning” signals in sepsis, being released from a site of localised infection and priming a systemic immune response.117 Two major subsets of EVs exist, microparticles and exosomes. Here, CD40LG is linked to Sepsis.