Results revealed that the key genes associated with pancreatic cancer were ALOX15 (arachidonate 15-lipoxygenase), CBS (cystathionine-β-synthase), FDFT1 (farnesyl diphosphate farnesyl transferase 1), LPCAT3 (lysophosphatidylcholine acyltransferase 3), RPL8 (ribosomal protein L8), TP53, and TTC35 (tetratricopeptide repeat domain 35), the expressions of which statistically significantly differed between normal tissues and pancreatic tumors of higher histological grades (Fig. 4e–k). Here, CBS is linked to familial pancreatic carcinoma.