TACSTD2 and neoplasm: To delineate global protein changes mediated by Trop2 oncogene in TNBC, we performed liquid chromatography with tandem mass spectrometry (LC–MS/MS) proteomic profiling of tumor samples from HCC1806 shCtrl and shTrop2 xenografts (Fig. 3a, b, Supplementary Fig. 2 and Supplementary Table 1).