Tumor-associated calcium signal transducer 2 (TACSTD2), also known as a human trophoblastic cell surface antigen 2 (Trop-2, Trop2), is a transmembrane glycoprotein and an emerging candidate for targeted cancer therapies due to its overexpression in various epithelial cancers and its association with tumor metastasis and poor prognosis across multiple epithelial cancers17–22. Here, TACSTD2 is linked to neoplasm.