In contrast, in line with the ability of TGF-β to control GzB and CD107 expression8, the maintenance of TGF-β signaling in effector T cells was sufficient to completely prevent the overactivation of their cytotoxic program as well as the repression of tumor growth we routinely observed in the absence of Itgβ8 expression on Tregs (Fig. 4d–g). This evidence concerns the gene ITGB8 and neoplasm.