ITGB8 and neoplasm: First, we confirmed that human T cells expressed ITGβ8 in the TME by analyzing single-cell mRNAseq, and reported that ITGB8 expression was prevalent in the Foxp3pos compartment of the TME of various tumor types, with 65-70% of Itgβ8pos T cells being Foxp3pos T cells (Supplementary Fig. 4).