Given the role of αvβ8 in TGF-β activation11, and the unique ability of the Itgβ8pos Treg subset to activate TGF-β1 compared to Itgβ8neg Tregs (Fig. 1i), we next assessed whether the repression of CD8pos T-cell cytotoxic functions in the TME of Foxp3ΔItgβ8 mice was due to an increase of the TGF-β signaling in the effector cells in the tumor. The gene discussed is TGFB1; the disease is neoplasm.