T lymphocytes (CD3pos), and particularly the CD4pos Foxp3pos (Treg) subset, composed the main portion of hematopoietic cells expressing Itgβ8, with approximately 80% of Itgβ8pos CD45pos cells being CD4pos Foxp3pos irrelevant of the tumor type (Fig. 1c–f). The gene discussed is ITGB8; the disease is neoplasm.