CD8A and cancer: Confirming the importance of TGF-β1 produced by cancer cells in the control of T-cell anti-tumor immune response, the phenotypical analysis of CD8 T cells from the TME of TGF-β1KO cancer cells showed at 2–3 times exacerbation of their cytotoxic markers than in TME of TGF-β1 sufficient cancer cells (Fig. 5f, g).