Although studies on other cancers also suggest an involvement of p32 in tumorigenesis and metastasis, recently it has been shown that targeting gC1qR at the C1q-binding site can significantly reduce mesothelioma tumor burden by increasing tumor cell apoptosis and decreasing tumor angiogenesis [33] and ablation of p32 induces apoptosis in colorectal cancer cells [34] but its role in melanoma remains mostly unknown. The gene discussed is C1QBP; the disease is colorectal cancer.