TGFB1 and neoplasm: GARP, a type I transmembrane cell-surface docking receptor for latent TGF-β, can interact with integrin subunits αV/β8 expressed on tumor cells and plays an important role in establishing the immunosuppressive TME through modulating Treg functions.20,21 The primary role of GARP in Treg was to regulate the availability of membrane-bound latent TGF-β and modulate its activation.20,21 Yet its role in myeloid cells was less defined.