CD274 and mesothelioma: Cytotoxic agents, including platinum, could modulate the immune response through PD-1/PD-L1 inhibition by enhancing the potential immunogenic effect.11–13 Combination regimens that include a PD-1 or PD-L1 inhibitor have led to prolonged OS in small cell lung cancer14 and non-small cell lung cancer.15 Previous reports have also shown that cytotoxic agents can induce immune-stimulating properties in mesothelioma cell models.16 17