Ten (55.6%) patients experienced grade 3 or greater AEs, including disorder of metabolism or nutrition, loss of appetite, anemia, hyponatremia, leukopenia, lymphocytopenia, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, pneumonia, nausea, colitis, diverticulitis, dental pulpitis, pulmonary embolism, peripheral neuropathy, and back pain. The gene discussed is GPT; the disease is Decreased total leukocyte count.