IL11 and bone metastasis: We found that this patient had somatically acquired deletions and amplifications in 17 of these genes (Fig. 5B); 8 of the genomic lesions were present in the primary tumor, including the MTDH, ANGPTL4, and ID1 genes associated with lung metastasis [46, 48]; and the IL11 and TGFB1 genes in which genomic alterations have been associated with bone metastasis [46, 49].