MTOR and rheumatoid arthritis: The KEGG analysis showed that differentially expressed genes were markedly enriched for [1] metabolism, including carbohydrate, amino acid, and antibiotics; [2] inflammatory responses, including “Toll-like receptor signaling pathway” and “Rheumatoid arthritis”; [3] signal transduction, including “TGF-beta signaling pathway”, “mTOR signaling pathway” and “Thyroid hormone signaling pathway”; and [4] catabolism, including “Peroxisome” and “Endocytosis” (Fig. 5).