It remains to be determined whether FAO could occur in microglial peroxisomes, but recent findings showing that inactivation of multifunctional protein-2 (MFP2), a pivotal enzyme in peroxisomal β-oxidation, leads to fatal neurological disorder characterized by microglial dysfunction suggest that peroxisomal β-oxidation may be an important and understudied facet of microglial metabolism [54]. The gene discussed is HSD17B4; the disease is nervous system disorder.