In this study, we examined the function of CPN1 in IBC and the results indicate that CPN1 is a negative indicator of OS and PFS in patients suffering from IBC.CPN1 over-expression was associated with poor clinicopathological features such as lymph node metastasis and the pathological stage (pTNM) (all P < 0.05). The gene discussed is CPN1; the disease is metastatic malignant neoplasm in the lymph nodes.