MLH1 and cancer: Using the approach of targeting genes associated to the participants’ specific cancer diagnoses yielded one more likely pathogenic variant: the MLH1 variant in participant A. The variant had been detected by Sanger sequencing performed at the Department of Clinical Genetics, Karolinska University Hospital, in 2012, but as it was synonymous and another nucleotide change at the same position was common in gnomAD, it was considered likely benign.